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Dietary fat, breast cancer debate continues NEW YORK, Mar 16 (Reuters Health) -- In the latest round of often conflicting research on the relationship between fat intake and breast cancer, an analysis of 13 studies suggests that lowering fat intake reduces blood levels of estrogen. And because estrogen exposure has been linked to breast cancer, the study suggests that reducing dietary fat might reduce breast cancer risk, according to the report in the March 17th issue of the Journal of the National Cancer Institute. A team of researchers at the University of Southern California Medical School in Los Angeles analyzed a total of 13 studies conducted between 1966 and 1998 -- a method known as a meta-analysis, which can reveal a link between two factors not obvious in individual studies. The combined results indicated that restricting fat intake lowered estrogen by 7.4% in premenopausal women and 23% in postmenopausal women. The overall reduction was 13.4%. In two studies, women restricted their fat intake to no more than 10% to 12% of their total calorie intake, and the fall in estrogen levels was the greatest in these two studies. In the remaining studies, fat intake was restricted to between 18% and 25% of total calories, still lower than the average diet in the US, which derives 34% of calories from fat. The studies indicate that "reducing fat consumption to below 20% of calories will reduce breast cancer risk," concluded Drs. Anna H. Wu, Malcolm C. Pike, and Daniel O. Stram. The investigators add, however, that there are no studies that adequately measure fat consumption in the population and breast cancer risk.
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