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WESTPORT, May 15 (Reuters Health) - Substitution of micronized progesterone for medroxyprogesterone acetate (MPA) decreases menopause-related symptoms and is likely to increase patients' compliance with hormone replacement therapy (HRT).

Dr. Lorraine Fitzpatrick of the Mayo Clinic in Rochester, Minnesota, and Dr. Brinda Wiita of Solvay Pharmaceuticals in Marietta, Georgia, surveyed 176 woman who had been using micronized progesterone for 1 to 6 months after being switched from MPA.

At doses of 100 to 400 mg q.d., 80% of the subjects reported excellent satisfaction with the new HRT regimen, and more than 65% reported improvement over the previous regimen. Vasomotor symptoms were improved in 50% of the subjects, anxiety and depression in 45%, and somatic symptoms in 32%. The subjects also reported improvements in sleep disturbance, menstrual problems, cognitive difficulties, and sexual functioning.

The authors conclude, in the May issue of the Journal of Women's Health, that "quality-of-life effects of natural progesterone are superior to MPA-containing regimens. These benefits combined with the positive effects on lipoproteins suggest that a micronized progesterone regimen may offer a wider spectrum of benefits for postmenopausal women."

J Women's Health 2000;9(4):1-7.

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