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Premenstrual Syndrome (PMS)

What is PMS?

PMS Issues...

I've seen lists of PMS symptoms that include dozens of complaints, but the most common symptoms include several or all of the following: bloating, weight gain, headache, backaches, irritability, depression, breast swelling or tenderness, loss of libido, and fatigue. Do these symptoms sound familiar? They are also the symptoms of estrogen dominance.

But the full range of symptoms includes confusion, disorientation, intemperate judgments, and decision making, moods swings, body aches, anger and verbal abuse, lethargy alternating with increased energy, alienation, guilt (at having your abused friends), lack of self-esteem, and cravings for sweets especially chocolate. Further, every system in the body can be affected: immune, digestive, circulatory, nervous, endocrine, and dermotologic (skin). Victims of PMS my experience any combination of the above and with all degrees of severity, from mild to overwhelming.

There are two important realities to understand about PMS. They are:

  1. YES, it is real.

  2. NO, you are not crazy.

The Role of Progesterone

More than a decade ago, after reading the work of Dr. Katherine Dalton in London, who defined PMS and found success using high-dose progesterone administered as rectal suppositories, many doctors decided to utilize natural progesterone cream in the treatment of their patients with PMS. The results were most impressive. The majority (but not all) of those patients reported remarkable improvements in their symptoms, including the elimination of their premenstrual water retention and weight gain. We have received hundreds of phone calls and letters from women and their doctors over the past few years who repot that PMS has been alleviated with the use of natural progesterone. Dr. Joel T. Hargrove of Vanderbilt University Medical Center has published results indicating a 90 percent success rate in treating PMS with natural progesterone.

PREMENSTRUAL SYNDROME (PMS) FURTHER DEFINITION & HISTORY

More than fifty years ago premenstrual tension was methodically investigated and described by Dr. Robert T. Frank of New York, although at the time he referred to Premenstrual Syndrome as premenstrual tension". PMS is now recognized the  world over as being a widespread problem. In 1931 Dr. Frank read his history making paper, "Hormonal Causes of Premenstrual Tension" at a meeting of the New York Academy of Medicine.

From 1931 on, many scientists who were investigating problems associated with menstruation were struck by the constant appearance of what they labeled premenstrual tension  (PMT). That was their umbrella term for  depression, extreme fatigue, and irritability. However as research continued it became clear that the "tension" evident during  the premenstrual time was  only part of what had to be called a syndrome. There were just too many other  symptoms that constantly occurred prior to menstruation. Important findings about the distressing symptoms of PMS, and in fact the term  Premenstrual Syndrome, came from the efforts of two English  physicians, Dr. Katharina Dalton, and Dr. Raymond Greene. In 1953  they published "The Premenstrual Syndrome" which was the first  PMS paper in medical literature (British Medical journal, 1, 1007).

A hormone is a chemical substance carried by the blood from one organ of the body to another which excites the organ to increased functional activity. Progesterone is a hormone, and as will be seen from reading the following pages, has been identified as playing the main role in PMS.

Dr. Dalton came to the use of progesterone through her own personal experience. She had noticed that her own menstrual migraines disappeared during the last six months of pregnancy. She concluded that the high levels of progesterone during pregnancy might have made the difference. She decided to test her theory personally. In the dual role of doctor and patient, she injected herself with progesterone every day. Just as she suspected, her menstrual migraines vanished. Dr. Dalton then tested the use of progesterone on other women with clear and rapid effect. That started what would become her well known advocacy of this now international treatment. Since 1953, Dr. Dalton has been the leading investigator of PMS and its foremost authority. She has published three books and more than 40  articles in leading medical journals about PMS. She has almost single  handedly been responsible for increasing interest in PMS by  physicians as well as concerned women throughout the world.  Other physicians have published books about PMS, though they always quote Dr. Dalton and her research.

Dr. Dalton describes the premenstrual syndrome as the commonest of endocrine disorders. The endocrine is our system of glands which passes secretions into the blood which act on specific organs. In her book, "The Premenstrual Syndrome", she says this title covers a wide variety of cyclical symptoms which regularly recur at the same phase of each menstrual cycle. The commonest time for repeated symptoms is during the premenstrum or early menstruation, but occasionally symptoms occur at ovulation. She says that the onset of the full menstrual flow usually brings dramatic and complete relief, but as there may be  slight menstrual loss for a day or two before the onset of full menstruation it is not uncommon to find symptoms continuing through the first day or two of each cycle.

Dr. Dalton feels that the term Premenstrual Tension should be avoided because tension reflects only one of many components of this syndrome and its use confuses the diagnosis where tension is absent or overshadowed by some more serious complaints. Also, she emphasizes that stressing psychological symptoms (symptomatology) makes it easy to imply that PMS is only a mere psychological problem.

Other researchers agree with Dr. Dalton. When they considered all the symptoms they decided that they were really facing a multi faceted, recurrent syndrome. Many varied symptoms are repeated during the monthly cycle. With all the facts before them, they settled on the term "premenstrual syndrome" (PMS) to describe the monthly symptoms  that women experienced. Premenstrual Tension, with all its debilitation effects, then became part of a larger premenstrual syndrome.

It has been recently reported in the New York Times that the estimated percentage of women with premenstrual syndrome ranges from 20% to 90%. Most frequently it is reported that 40%  of all women between the ages of 14 and 50 experience PMS. Of those women who suffer, an estimated 10 to 12 percent are noticing severely debilitating symptoms which disrupt their lives. 

 


Many women suffer from premenstrual syndrome (PMS) after ovulation and are frequently relieved when the next menstrual cycle begins. Specific problems—cramping, bloating, mood changes, and breast tenderness—may vary from woman to woman.

Dietary changes that may be helpful:

Women who eat more sugary foods appear to have an increased risk of PMS. Alcohol can effect hormone metabolism, and alcoholic women are more likely to suffer PMS. Tea consumption in China is strongly related to PMS. The same is true for coffee and other caffeine-containing beverages in the U.S. The more coffee women drink, the higher their risk. Therefore, many nutritionally oriented doctors recommend that women with PMS avoid sugar, alcohol, and caffeine.

Lifestyle changes that may be helpful:

It is well known that many women athletes do not menstruate. Exercise actually changes the way a woman's body metabolizes and eliminates estrogen, which seems to have dominance in women with PMS problems. After thirty days of regular, not necessarily strenuous, exercise, most women report a significant lessening of their symptoms. Nutritionally oriented doctors frequently recommend regular exercise as a way to reduce symptoms.

Herbs that may be helpful:

Wild Yam has a centuries long and worldwide history for its use in treating 'women's complaints'. Everywhere in the world where the yams grow, tribal medicine people have found it to be helpful in relieving cramps, mood swings, etc. The July 1992 National Geographic, in fact, contained a report of life on the Trobriand Islands (a small island group of SE New Guinea) where tribal diets are dedicated to the yam with other vegetables, and fish. The generally slim and happy people enjoy wonderful health (except for infectious diseases, like malaria), with a vigorous sexual life and (strangely, to the authors) fewer children than might be expected. The Islanders regard their life as idyllic, as do the occasional visitors. Of course National Geographic was not doing a story on herbal medicine, but the November issue contained several letters to the editor, explaining that the yams contained the sterol, diosgenin, with progesterone-like effects which accounts for the Trobriand Islander's idyllic, high energy lifestyle and low birth rate. Note: There are over 110 identified species of wild yams, some more potent in steroidal saponins than others and they yams commonly found in grocery stores in the US have little, if any, value hormonally.  Additionally, the best results have been obtained applying wild yam topically, in cream form, since stomach acids and enzymes tend to degrade the hormonal qualities of the yam before it gets into the system.  Orally, much higher amounts would have to be ingested.  See related products

Vitex has been shown to help re-establish normal balance of estrogen and progesterone during a woman’s menstrual cycle. This is important because some women will suffer from PMS and other menstrual irregularities due to underproduction of the hormone progesterone during the second half of their cycle. Vitex stimulates the pituitary gland to produce more luteinizing hormone, and this leads to greater production of progesterone. Studies have shown that using vitex over a period of several months will help normalize hormone balance and alleviate the symptoms of PMS. Use 20 drops of a liquid, concentrated vitex extract three times a day, or the capsule of the equivalent dried, powdered extract with some liquid. Vitex should be taken for at least four cycles to determine efficacy. has been shown to help re-establish normal balance of estrogen and progesterone during a woman’s menstrual cycle. This is important because some women will suffer from PMS and other menstrual irregularities due to underproduction of the hormone progesterone during the second half of their cycle. Vitex stimulates the pituitary gland to produce more luteinizing hormone, and this leads to greater production of progesterone. Studies have shown that using vitex over a period of several months will help normalize hormone balance and alleviate the symptoms of PMS. Use 20 drops of a liquid, concentrated vitex extract three times a day, or the capsule of the equivalent dried, powdered extract with some liquid. Vitex should be taken for at least four cycles to determine efficacy.

DonQuai (Angelica sinensis), in traditional Chinese medicine, is often referred to as the "female ginseng." DonQuai helps promote normal hormone balance and is particularly useful for women experiencing premenstrual cramping and pain. Many women take 2-3 grams of Dong quai capsules or tablets per day.

False Unicorn Root, used as medicine,  is based in Native American tradition, where it was recommended for a large number of women’s health conditions, including lack of menstruation (amenorrhea), painful menstruation, and other irregularities of menstruation, as well as to prevent miscarriages. Steroidal saponins are generally credited with providing false unicorn root’s activity. Modern investigations have not confirmed this, and there is no research yet about the medical applications of this herb.

Are there any side effects or interactions? Are there any side effects or interactions? Wild Yam has no reported side effects except an occasional personal allergy to the herb, which occurs in less than 1% of women taking wild yam.  Minor gastrointestinal upset and a mild skin rash with itching has been reported in less than 2% of the women monitored while taking vitex. Vitex is not recommended for use during pregnancy. It should not be taken together with synthetic hormone therapy. DonQuai may cause some fair-skinned persons to become more sensitive to sunlight. Persons using it on a regular basis should limit prolonged exposure to the sun or other sources of ultraviolet radiation. DonQuai is not recommended for pregnant or lactating women. No adverse effects have been reported with the use of false unicorn. Its long history of use in pregnant women suggests it may be safe for these individuals, but no studies have confirmed or denied it.

Nutritional supplements that may be helpful:

USP ProgesteroneUSP Progesterone, which is yam extract or soy extract that has been taken into the laboratory and given seven or eight enzyme baths, is an option for women who did not obtain results with yam extract in its natural state. It has not been chemically altered but rather enzymatically converted, which is why it can still be considered 'natural'. Mother Nature never intended for 'hormones' to be dropped into the stomach/GI tract, so it is best applied topically in cream form. The best creams contain both USP Progesterone and wild yam extract, which provides whole-plant constituents not present in the converted USP Progesterone creams.   See Related Product

Vitamin B6 can reduce effects of estrogen in animals, and excess estrogen may be responsible for PMS symptoms. A number of studies show that 200-400 mg of vitamin B6 per day for several months can relieve symptoms of PMS. Although the amount of vitamin B6 is sometimes too low, or the length of the trial too short, some studies have not found vitamin B6 helpful. Most nutritionally oriented doctors feel that vitamin B6 is worth a try and suggest 200-400 mg per day for at least three months. This amount can cause side effects. See the contraindications section below.

Many years ago, research linked B vitamin deficiencies to PMS. This work has only rarely been followed up, but some nutritionally oriented doctors still recommend the B-complex vitamins.

Women with PMS show abnormalities in the processing of fatty acids. In theory, these problems should resolve with evening primrose oil, or EPO. Of the double-blind trials, some report that EPO is quite helpful, while others find it no better than placebo. While the issue remains unresolved, many nutritionally oriented doctors consider EPO to be worth a try, suggesting 3-4 grams of EPO per day. EPO seems to work best when used over several cycles and may be more helpful in women with PMS who also experience breast tenderness or fibrocystic breast disease.

Women with PMS are often deficient in magnesium. Supplementing with magnesium may help reduce symptoms. While the ideal amount of magnesium has yet to be determined, some doctors recommend 400 mg per day. Women who consume more calcium from their diets are less likely to suffer severe PMS. Double-blind research has shown that supplementing 1,000 mg of calcium per day relieves symptoms in women with PMS.

Progesterone may relieve some symptoms of PMS and vitamin A appears to increase progesterone levels. Very high doses of vitamin A—100,000 IU per day or more—have reduced symptoms of PMS, but such an amount is dangerous. Women who are or who could become pregnant should not supplement with more than 10,000 IU (3,000 mcg) per day of vitamin A. Other people should not take 100,000 IU without the supervision of their nutritionally oriented doctor.

Although women with PMS don’t appear to be vitamin E deficient, double blind research shows that 300 IU of vitamin E per day may decrease symptoms of PMS.

Some of the nutrients mentioned above appear together in multi-vitamin/mineral supplements. One double-blind trial used multi-vitamin/mineral supplements containing vitamin B6 (600 mg per day), magnesium (500 mg per day), vitamin E (200 IU per day), vitamin A (25,000 IU per day), B-complex vitamins, plus other vitamins and minerals. In the trial, all four groups of women with PMS benefited more from supplements than from placebo. These results have been independently confirmed.

Are there any side effects or interactions? Although side effects from vitamin B6 supplements are rare, at very high levels this vitamin can damage sensory nerves, leading to numbness in the hands and feet as well as difficulty walking. Vitamin B6 supplementation should be stopped if these symptoms develop.

Taking too much magnesium often leads to diarrhea. This can happen at doses as low as 350-500 mg per day. Excessive magnesium intake is more serious but is rarely caused by magnesium supplements. People with kidney disease should not take calcium or magnesium supplements without consulting a physician. Individuals with sarcoidosis, hyperparathyroidism, or with chronic kidney disease should not supplement with calcium.

Women who are or could become pregnant should take less than 10,000 IU per day of vitamin A to avoid the risk of birth defects. For other adults, intake above 25,000 IU per day can in rare cases cause headaches, dry skin, hair loss, fatigue, bone problems, and liver damage.


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